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A study examining the effect of the immune receptor known as Toll-like Receptor 4, or TLR4, on how memory functions in both the normal and injured brain has found vastly different cellular pathways contribute to the receptor's effects on excitability in the uninjured and injured brain.
Concussion is a common childhood injury that may lead to long-term physical, behavioral, and neurocognitive effects, affecting learning and school performance. There is increasing concern about the potential for repeat concussions among professional and high school athletes, with specific attention focused on understanding how sustaining a concussion alters future concussion risk. Addressing repeat concussion risk among youth has substantial implications for clinical practice in terms of managing exposure — particularly regarding youth sports participation — and long-term health and development.
Post-traumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We performed a genome-wide association study and bioinformatic analyses, which included 146,660 European Americans and 19,983 African Americans in the US Million Veteran Program, to identify genetic risk factors relevant to intrusive reexperiencing of trauma, which is the most characteristic symptom cluster of PTSD. In European Americans, eight distinct significant regions were identified. Three regions had values of P < 5 × 10−10: CAMKV; chromosome 17 closest to KANSL1, but within a large high linkage disequilibrium region that also includes CRHR1; and TCF4. Associations were enriched with respect to the transcriptomic profiles of striatal medium spiny neurons. No significant associations were observed in the African American cohort of the sample. Results in European Americans were replicated in the UK Biobank data. These results provide new insights into the biology of PTSD in a well-powered genome-wide association study.
“You’re supposed to rest after concussion.” This advice has been given countless times to patients recovering from concussion. How did we get here, what is the evidence that brought us here, and what does the evolving evidence actually tell us?
A Harvard Medical School study published in Nature Communications shows a molecular relationship between TBI and CTE but also a possible treatment mechanism — just not one that can be used to treat humans quite yet.
Research findings suggest mild blast trauma suffered by military personnel affects portions of the auditory system that have not been extensively studied after injuries occur, and this impairment might be diagnosed using well-established testing methods.
A 2015 report from the Office of Government Accountability says the 32 peer-reviewed studies on the effectiveness of the HBOT for traumatic brain injury and post-traumatic stress came up with mixed results.
A Mayo Clinic study links amateur contact sports — football, boxing, wrestling, rugby, basketball, baseball and others played while in school — with the development of CTE, which when severe can affect mood, behavior, and cognition.