Rubenstein R, Chang B, Yue JK, et al. Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau–Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers. JAMA Neurol. 2017;74(9):1063–1072. doi:10.1001/jamaneurol.2017.0655
In a cohort study, plasma samples from the TRACK-TBI pilot study were collected at a single time point from 196 patients with acute traumatic brain injury and 21 patients with severe traumatic brain injury admitted to receive inpatient rehabilitation. Plasma phospho-tau levels and phospho tau–total tau ratio during the acute phase and chronic traumatic brain injury were superior to total-tau levels for discriminating the severity and status of neurotrauma patients from healthy controls.