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Members of the medical community literally take their lives in their hands every day they go to work. It’s hard not to feel a bit humbled by that courage. My first face-to-face encounter with First Responders was just over a decade ago. In November of 2010 fate saw fit that most of the First Responders from our Main Street Fire Station and I would meet.
A study examining the effect of the immune receptor known as Toll-like Receptor 4, or TLR4, on how memory functions in both the normal and injured brain has found vastly different cellular pathways contribute to the receptor's effects on excitability in the uninjured and injured brain.
BrainLine sat down with Dr. Edward C. Wright to discuss PTSD. Dr. Wright is a board-certified clinical psychologist in the Home Base Program of Massachusetts General Hospital, focused primarily on providing treatment for PTSD. He is also part of the Wounded Warrior Project’s® Warrior Care Network®, which helps veterans transition to civilian life. Dr. Wright spoke about PTSD and his use of cognitive-behavioral therapies to treat anxiety and depression.
This handout provides a brief summary of what researchers currently know and don’t know about chronic traumatic encephalopathy, or CTE. Research on CTE is growing, and more studies are needed to help answer many remaining questions. CDC will update this handout as more information on CTE becomes available.
Concussion is a common childhood injury that may lead to long-term physical, behavioral, and neurocognitive effects, affecting learning and school performance. There is increasing concern about the potential for repeat concussions among professional and high school athletes, with specific attention focused on understanding how sustaining a concussion alters future concussion risk. Addressing repeat concussion risk among youth has substantial implications for clinical practice in terms of managing exposure — particularly regarding youth sports participation — and long-term health and development.
Post-traumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We performed a genome-wide association study and bioinformatic analyses, which included 146,660 European Americans and 19,983 African Americans in the US Million Veteran Program, to identify genetic risk factors relevant to intrusive reexperiencing of trauma, which is the most characteristic symptom cluster of PTSD. In European Americans, eight distinct significant regions were identified. Three regions had values of P < 5 × 10−10: CAMKV; chromosome 17 closest to KANSL1, but within a large high linkage disequilibrium region that also includes CRHR1; and TCF4. Associations were enriched with respect to the transcriptomic profiles of striatal medium spiny neurons. No significant associations were observed in the African American cohort of the sample. Results in European Americans were replicated in the UK Biobank data. These results provide new insights into the biology of PTSD in a well-powered genome-wide association study.
“You’re supposed to rest after concussion.” This advice has been given countless times to patients recovering from concussion. How did we get here, what is the evidence that brought us here, and what does the evolving evidence actually tell us?