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Post-traumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We performed a genome-wide association study and bioinformatic analyses, which included 146,660 European Americans and 19,983 African Americans in the US Million Veteran Program, to identify genetic risk factors relevant to intrusive reexperiencing of trauma, which is the most characteristic symptom cluster of PTSD. In European Americans, eight distinct significant regions were identified. Three regions had values of P < 5 × 10⁻¹⁰: CAMKV; chromosome 17 closest to KANSL1, but within a large high linkage disequilibrium region that also includes CRHR1; and TCF4. Associations were enriched with respect to the transcriptomic profiles of striatal medium spiny neurons. No significant associations were observed in the African American cohort of the sample. Results in European Americans were replicated in the UK Biobank data. These results provide new insights into the biology of PTSD in a well-powered genome-wide association study.

A study comparing depression rates in men and women one year after moderate or severe TBI shows no significant gender differences in depression symptom levels. But researchers did find different patterns of other symptoms.

Early screening for alexithymia following TBI might identify those most at risk of having difficulty coping.

People who have both problematic anger and cognitive impairment after TBI may benefit from specific psychoeducational treatment.

Learn why it's better to "plan" than "avoid" after a brain injury.

An inability to perceive others’ emotions can make communication and social interactions difficult.

Treatment may help people with TBI decipher emotional clues.

A difficult skill to teach.