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Genome-wide association study of post-traumatic stress disorder reexperiencing symptoms in >165,000 US veterans

man in sweatshirt and a hat that says veteran

Post-traumatic stress disorder (PTSD) is a major problem among military veterans and civilians alike, yet its pathophysiology remains poorly understood. We performed a genome-wide association study and bioinformatic analyses, which included 146,660 European Americans and 19,983 African Americans in the US Million Veteran Program, to identify genetic risk factors relevant to intrusive reexperiencing of trauma, which is the most characteristic symptom cluster of PTSD. In European Americans, eight distinct significant regions were identified. Three regions had values of P < 5 × 10−10: CAMKV; chromosome 17 closest to KANSL1, but within a large high linkage disequilibrium region that also includes CRHR1; and TCF4. Associations were enriched with respect to the transcriptomic profiles of striatal medium spiny neurons. No significant associations were observed in the African American cohort of the sample. Results in European Americans were replicated in the UK Biobank data. These results provide new insights into the biology of PTSD in a well-powered genome-wide association study.

Acceptance

Nicole Bingaman and her son Taylor

Finding acceptance after a brain injury isn't easy. "For a long while, I bucked against our reality. I found myself caught between what I had once known and an uncertain future. The in-between caused marked turmoil. As much as I didn’t want to accept Taylor’s brain injury as part of our lives, it is. As much as I wish it didn’t affect Taylor and our family … it does." 

Who to Trust?

Who to Trust?

Of all the things I was warned about following TC’s brain injury diagnosis, no one suggested the idea of mistrust or suspicion. I didn’t anticipate waking up one day, twelve exhausting and painstaking months into his recovery, to find myself on trial, accused of harboring ulterior motives and secret plans...

The Big Picture

The Big Picture

Several hundred thousand service members have sustained TBI since 9/11. For most of these vets, the long-term challenge is dealing with profound changes in social skills and the ongoing demands of daily life.