What is CTE?

Dr. Perl describes chronic traumatic encephalopathy, or CTE.
CTE stands for chronic traumatic encephalopathy. And this is the disorder that has been described in primarily athletes who participate in contact sports. The first descriptions were in boxing, in boxers. And more recently has been widely discussed in the media, football players, professional football players, but this is expanded into hockey players and rugby players and soccer players and other examples that have been seen. But most of the discussion has either been in former boxers or in football players. CTE is undoubtedly related to the repeated head trauma related to the participation in contact sports. How repeated head trauma triggers this kind of degeneration in the brain and the tau accumulation we don’t understand as yet. But it’s very clear that it is related to the underlying repeated head trauma that one receives. It’s a chronic disease that’s what we call a neurodegenerative disease, but by and large the symptoms typically show up in the retirement years of these former athletes. It involves the accumulation of a protein called tau in nerve cells and other parts of the brain. It’s different than the scarring problem that we discussed about blast injury, although there is some overlap because some of the patients, or some of the cases, the specimens that we’ve looked at of individuals who have had blast injury who’ve survived for a significant number of years appear to be beginning to show the features of CTE. But we think of this as a late phenomenon down the road, years down the road from their exposure on the battlefield.
Posted on BrainLine December 13, 2017.

About the author: Daniel P. Perl, MD

Dr. Perl is a Professor of Pathology at USUHS and Director of the CNRM's Brain Tissue Repository, where he has established a state-of-the-art neuropathology laboratory dedicated to research on the acute and long-term effects of traumatic brain injury among military personnel.

Dr. Daniel P. Pearl