A brief summary of current research.
Kohl, AD, Wylie, GR, Genova, HM, Hillary, FG, DeLuca, J Brain Injury, Volume 23, Issue 5 May 2009, pp 420 – 432.
This study used functional magnetic resonance imaging (fMRI) to objectively assess cognitive fatigue in people with TBI. When performing a cognitive task, the participants with TBI showed increased brain activity over time, compared to the non-injured participants. This increased activity in various parts of the brain, which indicates increased cerebral "effort," might manifest as an individual’s feeling of cognitive fatigue.