The Ups and Downs of Changing Medications After Brain Injury

The Ups and Downs of Changing Medications After Brain Injury

I sustained a severe TBI more than 30 years ago in a car crash. My doctor recently recommended that I change my long-standing medication, Provigil (200mg once in the morning and once in the evening), to Nuvigil (250 mg once in the morning). I have been using Provigil for more than four years with no side effects. The new drug is causing chest pain and dizziness, nausea, and headaches. What is the danger of making a drug switch like this and where can I find more information on the use of Provigil and/or Nuvigil for the post-TBI profound fatigue?


Fatigue is a pervasive problem after traumatic brain injury, affecting 50-80 percent of patients with TBI living in the community. Although anecdotal reports suggest that Modafinil (Provigil) is helpful in treating fatigue in TBI, a controlled study failed to show consistent patterns of relief in a brain-injured population and it is not FDA indicated for this use. Despite this lack of evidence, modafinil continues to be widely used. Modafinil is, however, a recognized treatment option for under-arousal following TBI.

Here are two articles that discuss the use of modafinil (Provigil) for traumatic brain injury:

  1. Jha A, Weintraub A, Allshouse A, Morey C, Cusick C, Kittelson J, Harrison-Felix C, Whiteneck G, Gerber D. A randomized trial of modafinil for the treatment of fatigue and excessive daytime sleepiness in individuals with chronic traumatic brain injury. J Head Trauma Rehabil 2008;23(1):52-63.
  2. Elovic E. Use of provigil for underarousal following TBI. J Head Trauma Rehabil 2000;15(4):1068-1071.

I’m not aware of any literature discussing armodafinil (Nuvigil) for traumatic brain injury, although the manufacturer Cephalon has expressed interest publicly in investigating this.

Although modafinil and armodafinil are very similar and are reported to have a similar side effect profile, it is always wise to be cautious when changing from one to the other. Side effects should be discussed with your doctor so dosing can be optimized.

Posted on BrainLine April 23, 2012.

Comments (3)

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I noticed that I was much more sensitive to drugs I had been prescribed pre-TBI that I tried to continue post-TBI. I have heard this from other TBI patients but I don't know why it is or if there are any studies about it. I had taken Provigil before my TBI, prescribed at 200mg, 1x a day. I was uncomfortable with that dose after my TBI and can only tolerate 100mg 1x a day, with breaks every other day or so, otherwise it now messes up my sleep schedule. Almost a decade after my TBI, I am still struggling with getting back on a normal daily rhythm of activity and rest. I find that at best, I can stay more or less "on-task" for maybe 1 or 2 hours max. The effort to focus my thoughts and attention wears me out. I get extremely fatigued and sleepy. It would be good if modafinil and armodafinil were also recognized as a cognitive and energy aid for post-TBI patients, since most insurances don't cover it for anything other than narcolepsy.

I began taking nuvigil about three years post-TBI. To minimize side effects my dr started at a low dose twice a day and then gradually increased to the max 2x daily. The effect was immediate --I could see in 3-d and my attention span no longer stopped at 2 minutes. Have you had a sleep study done? Every time I went into rem sleep my oxygen levels dropped up to 20%, which the dr told me was really common post brain injury

Nuvigil is about 2x as strong as Provigil, from my own experience.