Ray was known as Razor to his friends and teammates. After a concussion three months ago Ray hasn’t seen much of his teammates, or for that matter, much of anyone. He has improved somewhat in the past few weeks. His headache is pretty much constant but low level. He still has light and noise sensitivity but his primary complaint is his inability to concentrate.
When he walked into our Concussion Management Clinic at the University at Buffalo he wore sunglasses and looked fairly depressed. His family doctor had heard about our program and liked the fact that we actively treat post concussion disorders and Ray was clearly not benefitting from the more typical approach of rest and withdrawal from activity.
Ray saw Dr. John Leddy, the director of the clinic, and told him how he was injured returning a punt for his varsity team. It was a helmet to helmet collision that Ray could describe because he had seen it on film. He had no memory of the event otherwise.
After determining that Ray’s symptoms and physical health were such that an exercise stress test would be safe, Dr. Leddy instructed Ray to change into his running shoes and track pants. Ray then nervously stepped on the treadmill. Our Physical Therapist, Scott, has conducted hundreds of these tests and knows just how to help athletes relax. Scott reinforced what Dr. Leddy had already told Ray, that he must not work through any changes in symptoms. Ray was instructed to report everything he experienced. During the treadmill test Scott asks every two minutes about changes in how Ray is feeling.
Ray started out well on the treadmill. In fact, he quite enjoyed doing a little exercise after so many months on the couch. He did not know it but his heart rate and blood pressure were increasing faster than they should for an athlete, even an athlete that has begun to de-condition. When his heart rate reached 160 beats per minute Ray suddenly felt strange and uncomfortable, even though it was not a particularly difficult level of exertion for him. Scott could see the change in Ray’s demeanor and immediately asked how he was feeling. Ray said he was feeling like someone had just tightened a rubber band around his head. Scott stopped the test immediately. Scott also observed that Ray’s heart rate and systolic blood pressure were unusually high for his level of exertion.
With the data from the exercise test in hand Dr. Leddy explained to Ray that indeed he was still suffering physiologic effects of his concussion. “However,” he said, “there is good news, as well. A heart rate of 152 means the recovery process is happening and we can speed that recovery process along.” Dr. Leddy then explained that Ray should exercise 20 minutes a day at a heart rate of 130 beats per minute and that after a few weeks we would increase the level of exercise based on his progress. A big smile came across Ray’s face. He could not believe that he could exercise again, even if it was at this relatively low level.
A few weeks later when it was determined that Ray could exercise to a heart rate of 178 beats per minute without exacerbation of symptoms, his exercise prescription was increased to 20 minutes at 160 beats per minute, two times a day. Ray could see the light at the end of the tunnel and it wasn’t far away.
Symptoms versus signs of concussion
Several weeks after Ray’s visit we heard from Dr. Sara Meagan, Ray’s family doctor. She was curious about the process we used to evaluate Ray’s post concussion disorder. She was especially curious about the use of an exercise stress test to evaluate Ray.
We began by explaining that most clinics diagnose concussion and post concussion disorder on the basis of symptoms. In fact, the DSM IV (Diagnostic and Statistical Manual of the American Psychiatric Association) and the World Health Organization definitions of post concussion disorders rely heavily on symptoms. Only the DSM IV asks also for evidence of a cognitive deficit based on cognitive testing. Symptoms, of course, are what the patient describes. These include headache, fatigue, sleep disturbance, vertigo, irritability, depression, apathy, sensitivity to light and/or noise, difficulty with concentration, etc.
Symptoms describe the subjective experience of the patient and are important to tell the doctor what the patient is feeling. However, for many diseases or disorders, symptoms are not sufficient to establish a diagnosis. Dr. Meagan was well aware that medical signs when detected by a physician provide a far more objective indication of disease or disorder. But she was unaware of the signs associated with concussion. We quickly summarized the relevant research on physiologic characteristics of individuals with post concussion disorders.
First and foremost, an individual’s resting heart rate is increased after traumatic brain injury.(King, Lichtman, Seliger, Ehert, & Steinberg, 1997) Perhaps more importantly, the rate at which the heart rate increases with exercise is accelerated in concussed patients. (B. Gall, W. S. Parkhouse, & D. Goodman, 2004) The heart rate increase seen with cognitive stress is also greater in concussed patients. (Hanna-Pladdy, Berry, Bennett, Phillips, & Gouvier, 2001)
Individuals with post concussion disorders also have autonomic nervous system dysregulation, which is expressed as overactive sympathetic nervous system activity. (B. Gall, W. Parkhouse, & D. Goodman, 2004; King, et al., 1997) Dr. Meagan remarked that this would explain why many patients complain of light sensitivity. She knew that pupils are dilated during sympathetic activity. We explained that it may also be responsible for why so many patients have difficulty falling asleep. In order to fall asleep, the parasympathetic system has to take charge, and an overactive sympathetic system prevents the individual from entering the relaxed state that is required in order to fall asleep.
Finally, we pointed out that patients with post concussion disorder often have difficulty regulating cerebral blood flow. (Junger et al., 1997) Simply put, the brain cannot perform well when the blood pressure in the brain is too high. During exercise or any other time that one experiences a substantial increase in blood pressure, the brain is protected by an auto-regulatory process. After a concussion this auto-regulatory process is disrupted. Dr. Meagan interrupted the educational program: “While I can certainly see the advantages to evaluation of signs versus symptoms of concussion, as a general practitioner I don’t see how I can assess someone for cerebral blood flow or autonomic nervous system balance in my practice”.
We pointed out that the disruption of regulatory processes is only revealed when the system is under stress. We only monitor cerebral blood flow during exercise and only in research. However, when we assess patients, like Ray, their inability to regulate cerebral blood flow becomes evident with the exacerbation of symptoms during exercise. Ray’s description of the “rubber band around my head” was typical of the subjective experience of excess blood flow to the brain.
“OK. Now your exercise test makes sense. But why did regulated exercise help Ray regain control of his regulatory processes?”
Regular exercise helps non-concussed individuals to become fit in part by improving regulatory control of cerebral blood flow and restoring autonomic nervous system balance. By prescribing an exercise program below the threshold at which Ray experienced distress, Ray was able to slowly regain his fit state. As an athlete, Ray’s recovery will be much faster but the same principles apply to non-athletes.
“Are there some who experience post concussion disorders for whom your exercise test and regulated exercise program is not appropriate?”
We do not recommend the test for patients who have ongoing symptoms after concussion unless the symptoms persist 3 weeks or more, after which the test is safe. We also do not recommend the test in patients with other health conditions that preclude exercise or increase the risk for a cardiac event during intense exercise. However, the test is very helpful in the differential diagnosis of the nature of the post concussion disorder. When someone is able to exercise fully without exacerbation of symptoms but still has problems, then we consider other causes. Some patients have ocular-vestibular difficulties or cervicogenic (neck) problems. There is also a group of patients who have anxiety or depressive disorders. So far we are only recommending the regulated exercise program for those with physiologic post concussion disorder (which we define as inability to exercise to exhaustion due to loss of regulatory control of cerebral blood flow during exercise).
Dr. Meagan thanked us for our time and indicated that she would be keen to learn how to assess patients herself. She has access to a treadmill and sees a substantial number of athletes from the local college. We explained that we have been providing training to clinicians at a number of programs and we would be happy to provide that training to her. We also explained that our research articles are available on our website: http://concussion.buffalo.edu.
Ray exercises to exhaustion without symptom exacerbation
It has been seven weeks since Ray first visited the Concussion Management Clinic at the University at Buffalo. He has been feeling better and, more important from his perspective, he has been able to return to school and perform up to his normal high
standards. But he was nervous once more as he approached the treadmill test. Scott reassured him that he is not likely to do any worse than before and since his last test was so good he was sure to do even better.
Ray was able to exercise to exhaustion without that feeling of tightness in his head or any other symptoms. In fact, he felt really good when he completed the treadmill test. He had not experienced the high that comes from a good workout since he had his concussion. He had forgotten how good it feels.
Meeting with Dr. Leddy to discuss the results, Ray could not stop smiling. Dr. Leddy’s assessment that he was fully recovered from his concussion came as no surprise, but it was reassuring to hear it from the doctor. Ray asked “So what happens now?”
Dr. Leddy indicated that since the football season was over there was no need to worry about return to play. He asked Ray how his studies were going and whether he was able to concentrate. Ray told him studying was no longer a problem. He also indicated that his sensitivity to noise and light was also not presenting a problem. Ray then indicated he was thinking of giving up football and wanted Dr. Leddy’s opinion. “Only you can decide how important football is in your life, but it is true that once you have had a concussion, especially one with long lasting physiologic effects, you are more likely to get a subsequent concussion, if that is what you are worrying about.”
“That is precisely what I am worried about. These past months have been difficult and have forced me to evaluate my priorities. I missed school more than I missed football.”
Ray is a fictional case based on a composite of a number of similar cases we have seen over the past few years since we started to use this physiologic approach to assessment and treatment of post concussion disorders. The chances for individuals with prolonged physiologic symptoms of concussion to improve and return to their normal level of function have improved dramatically over the past decade. In our research we found that 77% of patients recovered fully like Ray (Baker et al, 2012). In some instances, especially with non-athletes, patients who refuse to exercise have very poor outcomes. Those that do follow the exercise prescription but do not recover fully will have signs and
symptoms of other types of post concussion disorders. Among the most common disorders that did not fully recover with exercise were patients with ocular-vestibular symptoms and some patients, who despite being able to exercise to full capacity without symptom exacerbation, had persistent difficulty with concentration upon return to school or work.
Baker, JG; Freitas MS; Leddy, JJ; Kozlowski KF and Willer, BS (2012) “Return to full functioning after graded exercise assessment and progressive exercise treatment of postconcussive syndrome” Rehabilitation Research and Practice, Vol 2012; 705309, 7 pages.
Gall, B., Parkhouse, W., & Goodman, D. (2004). Heart rate variability of recently concussed athletes at rest and exercise. Med Sci Sports Exerc, 36(8), 1269-1274.
Gall, B., Parkhouse, W. S., & Goodman, D. (2004). Exercise following a sport induced concussion. Br J Sports Med, 38(6), 773-777.
Hanna-Pladdy, B., Berry, Z. M., Bennett, T., Phillips, H. L., & Gouvier, W. D. (2001). Stress as a diagnostic challenge for postconcussive symptoms: sequelae of mild traumatic brain injury or physiological stress response. Clin Neuropsychol, 15(3), 289-304.
Junger, E. C., Newell, D. W., Grant, G. A., Avellino, A. M., Ghatan, S., Douville, C. M., . . .
Winn, H. R. (1997). Cerebral autoregulation following minor head injury. J Neurosurg, 86(3), 425-432.
King, M. L., Lichtman, S. W., Seliger, G., Ehert, F. A., & Steinberg, J. S. (1997). Heart-rate variability in chronic traumatic brain injury. Brain Inj, 11(6), 445-453.
About the Authors
Barry Willer PhD is a Professor in the Department of Psychiatry at the State University of New York at Buffalo. He is co-founder of the Concussion Management Clinic at the University and serves as the clinic’s Director of Research. Dr. Willer has a long history of research on traumatic brain injury. In his earlier years he focused on issues related to long-term outcomes for moderate and severe brain injury. He authored the Community Integration Questionnaire, which is used in many brain injury programs and many different languages and countries. He is currently principal investigator of a NIDRR funded research project on the treatment of emotion recognition disorders in people with moderate and severe TBI. A little more than a decade ago he authored the first return to play following concussion guidelines for the International Olympics. He is currently involved in research on the physiology of concussion and just completed research on brain metabolism during post concussion disorders.
Dr. John J. Leddy is a board certified Internal Medicine and Sports Medicine physician. He is an Associate Professor of Clinical Orthopedics, Internal Medicine, and Rehabilitation Sciences at the University at Buffalo School of Medicine and Biomedical Sciences, and a Fellow of the American College of Sports Medicine and of the American College of Physicians. He is a practicing clinician and active researcher and teaches in the medical school. He is the Medical Director of the University at Buffalo Concussion Clinic, which is the first center in the United States to use a standardized exercise treadmill test to establish recovery from concussion and to use controlled exercise in the rehabilitation of patients with prolonged concussion symptoms. He is published in the fields of orthopedics, physiology, nutrition, concussion and post-concussion syndrome. His primary research interest is the investigation of the basic mechanisms of the disturbance of whole body physiology seen in concussion and how to help to restore the physiology to normal and so help patients to recover and safely return to activity and sport.
From Brain Injury Professional, the official publication of the North American Brain Injury Society, Vol. 9, Issue 1. Copyright 2012. Reprinted with permission of NABIS and HDI Publishers. For more information or to subscribe, visit: www.nabis.org.
Brain Injury Professional is the largest professional circulation publication on the subject of brain injury and is the official publication of the North American Brain Injury Society. Brain Injury Professional is published jointly by NABIS and HDI Publishers. Members of NABIS receive a subscription to BIP as a benefit of NABIS membership. Click here to learn more about membership in NABIS.
Please remember, we are not able to give medical or legal advice. If you have medical concerns, please consult your doctor. All posted comments are the views and opinions of the poster only.
Nick replied on Permalink
Very similar to Ray in the article im having pressure headaches with minor physical exertion that wont go away for 36-48 hrs.
Tried ignoring and working through it but 8 months later symptoms keep getting worse. Loss of balance, mental fog, poor short term memory.
Is there a doctor you can recommend in south florida who deals with sport injuries?
Tom replied on Permalink
When I was 5 years old I fell out of a tree house, hospitalized with concussion and broken left wrist.
When I was 13 I wiped out on a skateboard going 30 – 40 mph trying to break a speed record, hospitalized with a concussion
When I was 16 I broke my jaw in baseball taking a line drive hit from the pitching mound back to my right jaw, hospitalized with a concussion and broken jaw in two places.
When I was 4 years old I fell directly on the basement floor on my head from a monkey bar.
At 5, I went head first into a glass screen door, hospitalized with several stitches in back of my neck.
At 7 years old on my bike I ran into a car twice, went to doctor with bleeding tong and was told to eat nothing but jello and broth for 2 weeks.
At 9 years old, I had a PTSD incident
At 14 years old I had debilitating migraines and doctors could not find anything.
When I was 48, I was in a car accident but did not go to hospital until 2 days later due to pain
Played HS and College Football
Married at 26, divorced at 46, 3 kids (youngest is the only one who understands and she is getting her master’s in Public Health).
I have had memory problems, processing problems, comprehension issues, migraines and headaches my whole life.
I have been diagnosed with Neuropathy, Neuro Fatigue, Digentitive Disk Disease, Depression, insomnia, Tinnitus, Sleep Apnea, Bi Polar, Chronic pain and fatigue, Roasa, IBS, RA, Migraines, Digenitive Disk Disease, Hiatal Hernia, GERD, acid reflux, tarsal tunnel syndrome, social isolation, and entering Parkinson’s with stiff muscels and joints, internal shaking,
At 55 I am jobless, broke and trying to survive. In 2015 I started eating clean meditating, affirmations, exercise (lost 80 lbs.) but nothing working trying to do myself. Mental Deterioration .
Anonymous replied on Permalink
I am 11 months post concussion and continue to have symptoms that are exacerbated or brought on by exercise or intense concentration. I'm having difficulty finding the heart rate that brings on symptoms on my own. Do you know of a doctor or facility north of Dallas, Texas that can help me?
Mariann replied on Permalink
concussion-therapy.com is in Dallas. Not sure how far north you are, but many people have been helped through her integrative therapy approach.
Ask for Sally Fryer Dietz PT
Anonymous replied on Permalink
I am 25 years post concussion after a moderate brain injury, 30 minutes of unconsciousness and a long crack in my skull. Being a stubborn 21 year old, I refused to let this ruin my life and have lived a full life apart from about 3 days a month when I collapse with light sensitivity, inability to think, fatigue, severe pressure behind the eyes and emotional upheaval. I have always looked at this as being additional fluid retention from the menstrual cycle and my inability of regulating. Very early menopause unfortunately has not meant that the symptoms have ceased. Yoga, over a period of more than 6 months 2 years ago appears to have brought on migraine symptoms and severe head aches, jogging is no longer possible, because of the jolts and I am really struggling to find something that works for me. I am insisting on walking which feels great, but does seem to bring on headaches afterwards too. So after so many years of managing it relatively well on my own, and maintaining an active fitness level, I am now a little concerned that my condition is deteriorating with age. I am 46.
Anon1996m(TBI) replied on Permalink
Sorry- I’ve just come across your reply and I too am struggling with symptoms suddenly presenting 20+ yrs post head injury.
Have you ever been evaluated by a neuroendocrinologist? I sought one out following the discovery by VA research that a large proportion of vets who returned w TBIs were being misdiagnosed w PTSD when their symptoms were actually being caused by damage sustained to the hypothalamus or pituitary gland. I was actually diagnosed with Severe Adult Human Growth Hormone. Doc tested me for everything tho...
It’s just that your description of possible PMDD and early menopause may be due to damage to the part of your brain that controls the release of hormones. So it’s possible that others are being affected and contributing to other symptoms.
Anonymous replied on Permalink
I am now on my 8th concussion after not even getting out of the symptoms from my seventh but the section about the elevated resting heart rate and heart rate upon excercise is enlightening since I've had this problem for the past few years and doctors couldn't figure out why. Any time I excercise my heart rate will shoot over 200 very quickly and my resting heart rate is always around the 90-110 range.
Anonymous replied on Permalink
Is this an exit exertion test, or is this exertional therapy? Do you recommend providing an exit exertion test to all student athletes regardless of how long their post-concussive symptoms have lasted. Literature reveales that 80 to 90% of concussions return to baseline in 3-4 weeks, respectively.
Also, should a patient not have baseline exertion testing results on file, how do you compare post-concussive disorder treadmill result induced symptoms to what may or may not have been present before concussion with exertion?
Anonymous replied on Permalink
I am three weeks out from a concussion .
my nerves are shot and chest heavy . My doctor says to just rest and not work .
I am very frustrated with the overwhelming feelings I am experiencing since my concussion.
my thought follow through is not there .
any suggestions would be wonderful .
Anonymous replied on Permalink
This is very interesting as I am suffering from post concussion but also a yoga therapist for mental health with interest in the sympathetic & parasympathetic nervous system. I will not retain all the info but will look at again. Trying to do a little brain & body activity between resting. The worst part is sounds being so heightened & the tiredness. Hope in time will heal but accessing gp's here in London is not easy & rowed with them about this. Thankfully A & E emergency were great & diagnosed me.
joanna scott replied on Permalink
We are handling my 20 yr old daughters post concussion disorder now since just over 2 years. She auto manages, light and hearing sensitivity, but the cold sweat feet and disregulated eating and sleep including not getting to sleep still go on. Headaches are milder and less frequent by far, but if the cat knocks a book to the floor she jumps and can get head shocks as she calls them. The GP s were worse than useless to put it mildly had to go solo for now and follow instinct and my training in psychotherapy and intergrative bodywork.
I d say trust your inner voice and dont let anyone stop you from sleeping even 18 hours, we found that good sleep was the biggest turning point oh as well as reading the brain blogs. goodluck :)